4-Hydroxy-α-methyltryptamine (4-HO-aMT) or 4-ho-amt is a psychedelic drug of the tryptamine class. It is a close structural analogue of α-methyltryptamine (αMT) and produces similar effects to it, but with exacerbated side effects similarly to 5-MeO-aMT. Alexander Shulgin describes 4-HO-αMT briefly in his book TiHKAL.
Scientists have looked at 4-hydroxy analogue of αMT in human subjects. It has pronounce visual effects, some subjects said they had dizziness and a depressed feeling. There were, however, several toxic signs at doses of 15 to 20 milligrams orally, including abdominal pain, tachycardia, increased blood pressure and, with several people, headache and diarrhoea.
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Scientists have carried out very little studies about this compound on animals and humans. Thus, they have reported little information about the product. Therefore, no one really knows about long-term effects, dependency potential, toxicological risks, or possible contraindications.
4-ho-amt produces less mentally intense, though highly visual experiences relative to psychedelics like LSD, psilocin, and 4-AcO-DMT. The drug has this fair general characterization, but its tendency to be recreational and clearheaded should not be overstated. Some users experience strong mental effects at common doses and for a large portion of users it will eventually become intense if they use high doses. As is true for essentially all psychedelics, 4-ho-amt deserves respect and users should not treat it as a risk-free substance. A proper set and setting remain important factors for reducing the risks and enhancing the positive aspects of the drug.